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Title   유방암 예후인자로서의 EGFR 및 ER 표현에 관한 연구 ( A Study of Expression of EGFR and ER as Prognostic Factors of Breast Cancer )
Publicationinfo   1993 Jan; 025(03): 368-376.
Key_word   Breast cancer, Epidermal growth factor receptor(EGFR), Estrogen receptor(ER)
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Abstract   Relationship between epidermal growth factor receptor(EGFR)-estrogen receptor(ER) status and various prognostic factors was investigated in S5 human breast cancer tissues. EGFR was measured by immunohistochemical method(LSAB1 EGFR was positive in 36(42.4%) and estro- gen in 54(63.5%). A significant inverse relationship of the status between EGFR and ER was demonstrated by the pathological stage and histologic grade. In the cases of ER positive and EGFR negative, the proportion of stage I, II and histologic grade I, II was high, and in the cases of ER negative and EGFR positive, the proportion of stage III and histologic grade III was high. The more the positive grade of EGFR was increased, the more the proportion of ER value and histologic grade I was decreased. These data suggest that EGFR and ER status may be important prognostic factors of breast cancer, especially in EGFR as an indicator of high malignant potential.
저 자   이기범(Byung Soo Kim),정현철(Hyun Cheol Chung)